Commentary from IHI’s Ninon Lewis and Soma Stout are included in this article, which accompanied the publication’s release of its second annual Healthiest Communities ranking. Ninon’s remarks focus on the need for health systems to continue to think beyond the walls of traditional medical care in order to address the challenges which prevent people from staying healthy. Soma’s commentary highlights the existence of deep-rooted inequities in US communities which impact overall health and wellbeing.