To examine pragmatic approaches to incorporating genomics in learning health care systems, the IOM’s Roundtable on Translating Genomic-Based Research for Health hosted a workshop on December 8, 2014. A variety of stakeholder groups, including commercial developers, health information technology professionals, clinical providers, academic researchers, patient groups, and government and health system representatives, presented their perspectives and participated in discussions on maximizing the value that can be obtained from genomic information. The workshop examined how a variety of systems are capturing and making use of genomic data to generate knowledge for advancing health care in the 21st century. It also sought to evaluate the challenges, opportunities, and best practices for capturing or using genomic information in knowledge-generating health care systems.