NASA’s Human Research Program developed a collection of evidence reports that provide “the current record of the state of knowledge from research and operations” for more than 30 human health and performance risks related to long-duration and exploration spaceflights. To review NASA’s evidence reports, the IOM assembled a multi-disciplinary committee with expertise in aerospace medicine, occupational health, radiation medicine, human performance, systems engineering, human-computer interaction, internal medicine, physiology and cardiovascular health, immunology, behavioral health and sociology, task simulation and training, and biomedical informatics.