Longitudinal prospective studies that follow a population for an extended period (a decade or more) are the gold standard of observational epidemiologic studies, but they are uncommon due to great expense and time needed to conduct them. Even rarer are well-designed cohort studies that include the collection and storage of biospecimens for use in current and future analyses, such as the Air Force Health Study (AFHS). The AFHS is prospective epidemiologic study followed a cohort of 2,700 men for approximately 20 years.