Category: NEJM

Eviction and the Necessary Conditions for Health

Safe, affordable housing is a foundation of good health; it is essential to people’s ability to thrive in school and work and necessary for building strong families and communities. Housing markets and policies in the United States have failed to suppl…

The Drug-Dosing Conundrum in Oncology — When Less Is More

In May 2021, the Food and Drug Administration (FDA), where we work, approved sotorasib (Lumakras) for metastatic non–small-cell lung cancers (NSCLCs) harboring the KRAS p.G12C mutation. Sotorasib, which was approved on the basis of the phase 2 portion …

Vigilante Injustice — Deputizing and Weaponizing the Public to Stop Abortions

Texas Senate Bill (S.B.) 8: the “heartbeat” bill. Perhaps better described as the embryonic-cardiac-activity bill. It bans abortions a mere 5 or 6 weeks after the onset of the last menstrual cycle, even in cases of rape or when a woman’s health is in d…

Decarbonizing the U.S. Health Sector — A Call to Action

Nowhere are the effects of climate change manifesting more clearly than in human health. Although many people consider climate change a looming threat, health problems stemming from it already kill millions of people per year. It is well established th…

Methods of Public Health Research — Strengthening Causal Inference from Observational Data

Choosing wisely among possible courses of action requires knowledge about the effects of those actions. Public health and medical decision makers therefore need sound causal inferences to know what works and what harms people. Decision makers prefer in…

Integrating Research into Community Practice — Toward Increased Diversity in Clinical Trials

The Covid-19 pandemic has underscored health inequities affecting racial and ethnic minority and other underserved communities in the United States, highlighting, among other critical needs, the importance of increasing the diversity of participants in…

The No Surprises Act and Informed Financial Consent

At the close of 2020, the U.S. Congress passed the No Surprises Act to end the pernicious practice of so-called surprise billing for out-of-network care. But the country’s recent experience with balance-billing prohibitions for Covid-19 testing and tre…

Striving for Diversity in Research Studies

Physicians often find it challenging to apply the lessons of large research studies to their clinical practice, especially when the research participants do not reflect the racial identity, ethnicity, age, or sex and gender of the physicians’ patients….

Toward a New Era for the Indian Health System

There are institutional failures, and there are institutions that have been set up to fail. Imagine a health care system that spends less than half as much per person as the national average, delivers care in outdated clinics and hospitals, and has chr…

Race in Medicine — Genetic Variation, Social Categories, and Paths to Health Equity

What is race? Should medicine stop using racial and ethnic categories as proxies for social determinants of health, genetic ancestry, or both? What are the most promising approaches to dismantling structural racism in medicine? In this video roundtable…