William A. Haseltine, Contributor

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Additional Support Arrives For The Covid-19 Test-To-Treat Program

The Biden Administration’s Test-to-treat program has the potential to transform the pandemic, especially for those at high risk of severe disease.

The Center For Forecasting And Outbreak Analytics Could Represent A New Era In Infectious Disease Control, But Challenges Lie Ahead

The CDC’s new Center for Forecasting and Outbreak Analytics aims to act in a similar way to the weather forecast to guide decisions about broad public health needs. But the system will only be as effective as the data it receives.

SARS-CoV-2 Infection Causes Cell Fusion In The Lungs, Triggering Inflammation.

Hyperinflammation is responsible for much of the damage in acute Covid-19. Generalized inflammation is a major contributor to long Covid. New research suggests that the SARS-CoV-2 spike protein can induce syncytia formation in the lungs, triggering a s…

The Role Of N Protein Mutant Variants As Determinants Of SARS-CoV-2 Replication And Pathogenesis

A recent study found that N protein mutations common in many variants of concern play a major role in transmissibility and virulence.

STING-Mediated Innate Immunity: How One Discovery Unlocked New Possibilities

Activating STING-mediated innate immunity requires second messenger molecules to bind onto the protein. In this next part of our series, we will delve deeper into the discovery that uncovered a new group of second messengers that may help to control in…

SARS-CoV-2 Mimics Inflammatory Proteins In Our Body

Inflammation is one of the most serious consequences of infection and is a hallmark of severe SARS-CoV-2. Recent studies show that SARS-CoV-2 induces the innate immune system’s inflammatory response by mimicking one of our body’s most potent inflammato…

Survival Of The Fittest: The Rise Of BA.2.12.1

The latest Omicron variant, BA.2.12.1, is on the rise in the American Northeast. Here we describe what may be the next catalyst for infections in the US and worldwide.

STING: It Takes Two To Tango

A new discovery uncovered a previously hidden binding site on a key immune protein known as STING that may enhance protection against infection. Knowing when to activate or inhibit this protein may be the key to controlling the widespread inflammatory …

SARS-CoV-2 Infection Of Monocytes Triggers Inflammation

Hyper-inflammation is a hallmark of severe Covid-19. New research shines a light onto one of the potential causes: infection of monocytes and macrophages.

New Members Of The Omicron Family Of Viruses: BA.2.12.1, BA.4, And BA.5

New members of the Omicron family continue to emerge. Here we describe descendants of the highly transmissible BA.2 tree.