Since December, lineages of SARS-CoV-2 containing mutations at the 677 amino acid site have been appearing in Louisiana and New Mexico with increasing frequency. How does this fit into the bigger picture of viral variation?
A recent study from the Harvard University School of Public Health suggests that B.1.1.7 may even remain in human hosts nearly twice as long as non-B.1.1.7 SARS-CoV-2, extending the potential contagious period from about eight days to thirteen days.
This week, the UK government approved vaccine challenge trials — a study set to deliberately infect healthy people with SARS-CoV-2. But the trial holds a real risk to the healthy volunteers who will be recruited for the trial.
In August, Italian researchers found that a persistently infected Covid-19 patient had a mutation in the 501 site. A month later, a variant with a key mutation in the same site—the UK variant—was reported for the first time.
Declining case rates in some areas do not tell the full story as we are now witnessing the rapid spread of new variants. We need to swiftly implement vigilant public health protocols and expand genomic surveillance.
Most of the adverse outcomes we’ve attributed to the new SARS-CoV-2 variants, we trace back to point mutations located in the receptor binding domain. But they also have mutations in the N-terminal domain that we’d be remiss to neglect.
Experts have posited that women tend to live longer than men because they age more slowly, and due to their ability to fend off disease better when they do get sick, at any age. But, biology – for example, the role of hormones – can only explain so much.