For many people with autoimmune disease, fatigue is the most debilitating symptom. Why autoimmune disease and fatigue go together is not entirely understood, although inflammation may be part of the reason. Other possible factors include pain, poor sleep, inactivity, and depressed mood. Fatigue is not just feeling tired. Fatigue is composed of both physical fatigue
Crippling fatigue: a common enemy of autoimmune disease originally appeared in KevinMD.com.